Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f (−/−) mice were protected from death after cecal lig...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Izawa, Kumi, Maehara, Akie, Isobe, Masamichi, Yasuda, Yuka, Urai, Makoto, Hoshino, Yasutaka, Ueno, Keigo, Matsukawa, Toshihiro, Takahashi, Mariko, Kaitani, Ayako, Shiba, Emiko, Takamori, Ayako, Uchida, Shino, Uchida, Koichiro, Maeda, Keiko, Nakano, Nobuhiro, Yamanishi, Yoshinori, Oki, Toshihiko, Voehringer, David, Roers, Axel, Nakae, Susumu, Ishikawa, Junko, Kinjo, Yuki, Shimizu, Toshiaki, Ogawa, Hideoki, Okumura, Ko, Kitamura, Toshio, Kitaura, Jiro
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487349/
https://ncbi.nlm.nih.gov/pubmed/28655892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04647-z
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