Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f (−/−) mice were protected from death after cecal lig...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Izawa, Kumi, Maehara, Akie, Isobe, Masamichi, Yasuda, Yuka, Urai, Makoto, Hoshino, Yasutaka, Ueno, Keigo, Matsukawa, Toshihiro, Takahashi, Mariko, Kaitani, Ayako, Shiba, Emiko, Takamori, Ayako, Uchida, Shino, Uchida, Koichiro, Maeda, Keiko, Nakano, Nobuhiro, Yamanishi, Yoshinori, Oki, Toshihiko, Voehringer, David, Roers, Axel, Nakae, Susumu, Ishikawa, Junko, Kinjo, Yuki, Shimizu, Toshiaki, Ogawa, Hideoki, Okumura, Ko, Kitamura, Toshio, Kitaura, Jiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487349/
https://ncbi.nlm.nih.gov/pubmed/28655892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04647-z
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