Disrupting ceramide-CD300f interaction prevents septic peritonitis by stimulating neutrophil recruitment

Sepsis is a serious clinical problem. Negative regulation of innate immunity is associated with sepsis progression, but the underlying mechanisms remains unclear. Here we show that the receptor CD300f promotes disease progression in sepsis. CD300f (−/−) mice were protected from death after cecal lig...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Izawa, Kumi, Maehara, Akie, Isobe, Masamichi, Yasuda, Yuka, Urai, Makoto, Hoshino, Yasutaka, Ueno, Keigo, Matsukawa, Toshihiro, Takahashi, Mariko, Kaitani, Ayako, Shiba, Emiko, Takamori, Ayako, Uchida, Shino, Uchida, Koichiro, Maeda, Keiko, Nakano, Nobuhiro, Yamanishi, Yoshinori, Oki, Toshihiko, Voehringer, David, Roers, Axel, Nakae, Susumu, Ishikawa, Junko, Kinjo, Yuki, Shimizu, Toshiaki, Ogawa, Hideoki, Okumura, Ko, Kitamura, Toshio, Kitaura, Jiro
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487349/
https://ncbi.nlm.nih.gov/pubmed/28655892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04647-z
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