Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer

Increasing evidence shows that competitive endogenous RNAs (ceRNAs) can affect the expression of other transcripts by sequestering common microRNAs (miRNAs), and participate in tumourigenesis. As a potent tumour suppressor in colorectal cancer (CRC), SMAD4 is regulated by many miRNAs. However, the r...

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Publicat a:Sci Rep
Autors principals: Wang, Zaozao, Yang, Jie, Di, Jiabo, Cui, Ming, Xing, Jiadi, Wu, Fan, Wu, Wei, Yang, Hong, Zhang, Chenghai, Yao, Zhendan, Zhang, Nan, Jiang, Beihai, Su, Xiangqian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487320/
https://ncbi.nlm.nih.gov/pubmed/28655924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04368-3
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