Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus’s natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter

When confronted with poor oxygenation, cells adapt by activating survival signaling pathways, including the oxygen-sensitive transcriptional regulators called hypoxia-inducible factor alphas (HIF-αs). We report here that HIF-1α also regulates the life cycle of Epstein-Barr virus (EBV). Incubation of...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Kraus, Richard J., Yu, Xianming, Cordes, Blue-leaf A., Sathiamoorthi, Saraniya, Iempridee, Tawin, Nawandar, Dhananjay M., Ma, Shidong, Romero-Masters, James C., McChesney, Kyle G., Lin, Zhen, Makielski, Kathleen R., Lee, Denis L., Lambert, Paul F., Johannsen, Eric C., Kenney, Shannon C., Mertz, Janet E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487075/
https://ncbi.nlm.nih.gov/pubmed/28617871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006404
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