Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Gain-of-function mutations in KCNJ2-encoded Kir2.1 channels underlie variant 3 (SQT3) of the short QT syndrome, which is associated with atrial fibrillation (AF). Using biophysically-detailed human atria computer models, this study investigated the mechanistic link between SQT3 mutations and atrial...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Whittaker, Dominic G., Ni, Haibo, El Harchi, Aziza, Hancox, Jules C., Zhang, Henggui
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5487071/
https://ncbi.nlm.nih.gov/pubmed/28609477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005593
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