Essential role of RSK2 in c-Fos–dependent osteosarcoma development

Inactivation of the growth factor–regulated S6 kinase RSK2 causes Coffin-Lowry syndrome in humans, an X-linked mental retardation condition associated with progressive skeletal abnormalities. Here we show that mice lacking RSK2 develop a progressive skeletal disease, osteopenia due to impaired osteo...

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Autors principals: David, Jean-Pierre, Mehic, Denis, Bakiri, Latifa, Schilling, Arndt F., Mandic, Vice, Priemel, Matthias, Idarraga, Maria Helena, Reschke, Markus O., Hoffmann, Oskar, Amling, Michael, Wagner, Erwin F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2005
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC548699/
https://ncbi.nlm.nih.gov/pubmed/15719069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522877
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