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Synthesis and Opioid Activity of Tyr(1)–ψ[(Z)CF=CH]–Gly(2) and Tyr(1)–ψ[(S)/(R)-CF(3)CH–NH]–Gly(2) Leu-enkephalin Fluorinated Peptidomimetics
We describe the design, synthesis, and opioid activity of fluoroalkene (Tyr(1)–ψ[(Z)CF=CH]–Gly(2)) and trifluoroethylamine (Tyr(1)–ψ[(S)/(R)-CF(3)CH–NH]–Gly(2)) analogues of the endogenous opioid neuropeptide, Leu-enkephalin. The fluoroalkene peptidomimetic exihibited low nanomolar functional activi...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5486982/ https://ncbi.nlm.nih.gov/pubmed/28296145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201700103 |
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