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Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism

Connector enhancer of KSR (CNK), an essential component of Drosophila receptor tyrosine kinase/mitogen-activated protein kinase pathways, regulates oppositely RAF function. This bimodal property depends on the N-terminal region of CNK, which integrates RAS activity to stimulate RAF and a bipartite e...

詳細記述

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書誌詳細
主要な著者: Laberge, Gino, Douziech, Mélanie, Therrien, Marc
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC548663/
https://ncbi.nlm.nih.gov/pubmed/15660123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600558
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