Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Immune checkpoint inhibitors have significantly improved the treatment of several cancers. T-cell infiltration and the number of neoantigens caused by tumor-specific mutations are correlated to favorable responses in cancers with a high mutation load. Accordingly, checkpoint immunotherapy is thought...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Layer, Julian P., Kronmüller, Marie T., Quast, Thomas, van den Boorn-Konijnenberg, Debby, Effern, Maike, Hinze, Daniel, Althoff, Kristina, Schramm, Alexander, Westermann, Frank, Peifer, Martin, Hartmann, Gunther, Tüting, Thomas, Kolanus, Waldemar, Fischer, Matthias, Schulte, Johannes, Hölzel, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5486176/
https://ncbi.nlm.nih.gov/pubmed/28680756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1320626
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