The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma

Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine....

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Int J Mol Sci
Main Authors: Thongkum, Angkana, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, Navasumrit, Panida, Parnlob, Varabhorn, Sricharunrat, Thaniya, Bhudhisawasdi, Vajarabhongsa, Ruchirawat, Mathuros, Savaraj, Niramol
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI 2017
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485998/
https://ncbi.nlm.nih.gov/pubmed/28587170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18061175
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