The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma

Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine....

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Thongkum, Angkana, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, Navasumrit, Panida, Parnlob, Varabhorn, Sricharunrat, Thaniya, Bhudhisawasdi, Vajarabhongsa, Ruchirawat, Mathuros, Savaraj, Niramol
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485998/
https://ncbi.nlm.nih.gov/pubmed/28587170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18061175
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