The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma

Argininosuccinate synthetase (ASS), a key enzyme to synthesize arginine is down regulated in many tumors including hepatocellular carcinoma (HCC). Similar to previous reports, we have found the decrease in ASS expression in poorly differentiated HCC. These ASS(-) tumors are auxotrophic for arginine....

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Publié dans:Int J Mol Sci
Auteurs principaux: Thongkum, Angkana, Wu, Chunjing, Li, Ying-Ying, Wangpaichitr, Medhi, Navasumrit, Panida, Parnlob, Varabhorn, Sricharunrat, Thaniya, Bhudhisawasdi, Vajarabhongsa, Ruchirawat, Mathuros, Savaraj, Niramol
Format: Artigo
Langue:Inglês
Publié: MDPI 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485998/
https://ncbi.nlm.nih.gov/pubmed/28587170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18061175
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