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Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation

Liver receptor homolog 1 (LRH-1) is an orphan nuclear receptor that synergizes with β-catenin/T cell factor 4 signaling to stimulate intestinal crypt cell renewal. We evaluated here the impact of haploinsufficiency of LRH-1 on intestinal tumorigenesis by using two independent mouse models of human c...

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Autors principals: Schoonjans, Kristina, Dubuquoy, Laurent, Mebis, Joseph, Fayard, Elisabeth, Wendling, Olivia, Haby, Céline, Geboes, Karel, Auwerx, Johan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC548586/
https://ncbi.nlm.nih.gov/pubmed/15684064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409756102
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