Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development

Invasive fungal infections cause significant morbidity and mortality in part due to a limited antifungal drug arsenal. One therapeutic challenge faced by clinicians is the significant host toxicity associated with antifungal drugs. Another challenge is the fungistatic mechanism of action of some dru...

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Bibliographic Details
Published in:Microbiol Mol Biol Rev
Main Authors: Thammahong, Arsa, Puttikamonkul, Srisombat, Perfect, John R., Brennan, Richard G., Cramer, Robert A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485801/
https://ncbi.nlm.nih.gov/pubmed/28298477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MMBR.00053-16
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