A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation

BACKGROUND: Kv1.3 potassium channels regulate microglial functions and are overexpressed in neuroinflammatory diseases. Kv1.3 blockade may selectively inhibit pro-inflammatory microglia in neurological diseases but the molecular and cellular mechanisms regulated by Kv1.3 channels are poorly defined....

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Rangaraju, Srikant, Raza, Syed Ali, Pennati, Andrea, Deng, Qiudong, Dammer, Eric B., Duong, Duc, Pennington, Michael W., Tansey, Malu G., Lah, James J., Betarbet, Ranjita, Seyfried, Nicholas T., Levey, Allan I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485721/
https://ncbi.nlm.nih.gov/pubmed/28651603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-0906-6
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