Model‐Informed Development and Registration of a Once‐Daily Regimen of Extended‐Release Tofacitinib

Extended‐release (XR) formulations enable less frequent dosing vs. conventional (e.g., immediate release (IR)) formulations. Regulatory registration of such formulations typically requires pharmacokinetic (PK) and clinical efficacy data. Here we illustrate a model‐informed, exposure–response (E‐R) a...

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Detaylı Bibliyografya
Yayımlandı:Clin Pharmacol Ther
Asıl Yazarlar: Lamba, M, Hutmacher, MM, Furst, DE, Dikranian, A, Dowty, ME, Conrado, D, Stock, T, Nduaka, C, Cook, J, Krishnaswami, S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2017
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485720/
https://ncbi.nlm.nih.gov/pubmed/27859030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.576
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