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Extended‐Release Once‐Daily Formulation of Tofacitinib: Evaluation of Pharmacokinetics Compared With Immediate‐Release Tofacitinib and Impact of Food

Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis. An extended‐release (XR) formulation has been designed to provide a once‐daily (QD) dosing option to patients to achieve comparable pharmacokinetic (PK) parameters to the twice‐daily immediate‐release (IR) formu...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Lamba, Manisha, Wang, Rong, Fletcher, Tracey, Alvey, Christine, Kushner, Joseph, Stock, Thomas C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5113768/
https://ncbi.nlm.nih.gov/pubmed/26970526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.734
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