Model‐Informed Development and Registration of a Once‐Daily Regimen of Extended‐Release Tofacitinib

Extended‐release (XR) formulations enable less frequent dosing vs. conventional (e.g., immediate release (IR)) formulations. Regulatory registration of such formulations typically requires pharmacokinetic (PK) and clinical efficacy data. Here we illustrate a model‐informed, exposure–response (E‐R) a...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Lamba, M, Hutmacher, MM, Furst, DE, Dikranian, A, Dowty, ME, Conrado, D, Stock, T, Nduaka, C, Cook, J, Krishnaswami, S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485720/
https://ncbi.nlm.nih.gov/pubmed/27859030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.576
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