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T-bet antagonizes mSin3a recruitment and transactivates a fully methylated IFN-γ promoter via a conserved T-box half-site
Promoter DNA methylation is a major epigenetic mechanism for silencing genes and establishing commitment in cells differentiating from their precursors. The transcription factor T-bet is a key determinant of IFN-γ gene expression in helper T cells, but the mechanisms by which it achieves this effect...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548570/ https://ncbi.nlm.nih.gov/pubmed/15684083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409510102 |
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