Structure and mechanism of IFN-γ antagonism by an orthopoxvirus IFN-γ-binding protein

Ectromelia virus (ECTV) encodes an IFN-γ-binding protein (IFN-γBP(ECTV)) that disrupts IFN-γ signaling and its ability to induce an antiviral state within cells. IFN-γBP(ECTV) is an important virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the cau...

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Autori principali: Nuara, Anthony A., Walter, Leigh J., Logsdon, Naomi J., Yoon, Sung Il, Jones, Brandi C., Schriewer, Jill M., Buller, R. Mark, Walter, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2542861/
https://ncbi.nlm.nih.gov/pubmed/18252829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705753105
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