AAV-mediated pancreatic overexpression of Igf1 counteracts progression to autoimmune diabetes in mice

OBJECTIVE: Type 1 diabetes is characterized by autoimmune destruction of β-cells leading to severe insulin deficiency. Although many improvements have been made in recent years, exogenous insulin therapy is still imperfect; new therapeutic approaches, focusing on preserving/expanding β-cell mass and...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Mallol, Cristina, Casana, Estefania, Jimenez, Veronica, Casellas, Alba, Haurigot, Virginia, Jambrina, Claudia, Sacristan, Victor, Morró, Meritxell, Agudo, Judith, Vilà, Laia, Bosch, Fatima
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485311/
https://ncbi.nlm.nih.gov/pubmed/28702323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.05.007
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