Insulin-like Growth Factor 2 Overexpression Induces β-Cell Dysfunction and Increases Beta-cell Susceptibility to Damage

The human insulin-like growth factor 2 (IGF2) and insulin genes are located within the same genomic region. Although human genomic studies have demonstrated associations between diabetes and the insulin/IGF2 locus or the IGF2 mRNA-binding protein 2 (IGF2BP2), the role of IGF2 in diabetes pathogenesi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Casellas, Alba, Mallol, Cristina, Salavert, Ariana, Jimenez, Veronica, Garcia, Miquel, Agudo, Judith, Obach, Mercè, Haurigot, Virginia, Vilà, Laia, Molas, Maria, Lage, Ricardo, Morró, Meritxell, Casana, Estefania, Ruberte, Jesús, Bosch, Fatima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505425/
https://ncbi.nlm.nih.gov/pubmed/25971976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.642041
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