Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass

Type 2 diabetes (T2D) results from insulin resistance and inadequate insulin secretion. Insulin resistance initially causes compensatory islet hyperplasia that progresses to islet disorganization and altered vascularization, inflammation, and, finally, decreased functional β-cell mass and hyperglyce...

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Detalhes bibliográficos
Main Authors: Agudo, Judith, Ayuso, Eduard, Jimenez, Veronica, Casellas, Alba, Mallol, Cristina, Salavert, Ariana, Tafuro, Sabrina, Obach, Mercè, Ruzo, Albert, Moya, Marta, Pujol, Anna, Bosch, Fatima
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478542/
https://ncbi.nlm.nih.gov/pubmed/22961079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0134
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