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Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases

Inositol pyrophosphates physiologically regulate vesicular endocytosis, ribosomal disposition, and directly phosphorylate proteins. Here we demonstrate roles in cell death and regulation of telomere length. Lethal actions of wortmannin and caffeine are selectively abolished in yeast mutants that can...

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Detalhes bibliográficos
Main Authors: Saiardi, Adolfo, Resnick, Adam C., Snowman, Adele M., Wendland, Beverly, Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC548528/
https://ncbi.nlm.nih.gov/pubmed/15665079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409322102
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