Uncoupling protein 2 regulates daily rhythms of insulin secretion capacity in MIN6 cells and isolated islets from male mice

OBJECTIVE: Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); however, the physiological function of UCP2 in the β ce...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Seshadri, Nivedita, Jonasson, Michael E., Hunt, Kristin L., Xiang, Bo, Cooper, Steven, Wheeler, Michael B., Dolinsky, Vernon W., Doucette, Christine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
Brief Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5485245/
https://ncbi.nlm.nih.gov/pubmed/28702331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.04.008
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