The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis

BACKGROUND: Reactive oxygen species and tissue remodeling regulators, such as metalloproteinases (MMPs) and their inhibitors (TIMPs), are thought to be involved in the development of pulmonary fibrosis. We investigated these factors in the fibrotic response to bleomycin of p47(phox )-/- (KO) mice, d...

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Autori principali: Manoury, Boris, Nenan, Soazig, Leclerc, Olivier, Guenon, Isabelle, Boichot, Elisabeth, Planquois, Jean-Michel, Bertrand, Claude P, Lagente, Vincent
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2005
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC548519/
https://ncbi.nlm.nih.gov/pubmed/15663794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-6-11
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