Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a pernicious lung disease characterized by alveolar epithelial apoptosis, dysregulated repair of epithelial injury, scar formation, and respiratory failure. In this study, we identified phospholipase D (PLD)-generated phosphatidic acid (PA) signaling in the dev...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Suryadevara, Vidyani, Huang, Longshuang, Kim, Seok-Jo, Cheresh, Paul, Shaaya, Mark, Bandela, Mounica, Fu, Panfeng, Feghali-Bostwick, Carol, Di Paolo, Gilbert, Kamp, David W., Natarajan, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734379/
https://ncbi.nlm.nih.gov/pubmed/31090437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00320.2018
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