Alternative tRNA Priming of Human Immunodeficiency Virus Type 1 Reverse Transcription Explains Sequence Variation in the Primer-Binding Site That Has Been Attributed to APOBEC3G Activity

It is generally assumed that human immunodeficiency virus type 1 (HIV-1) uses exclusively the cellular [Formula: see text] molecule as a primer for reverse transcription. We demonstrate that HIV-1 uses not only [Formula: see text] but also an alternative tRNA primer. This tRNA was termed [Formula: s...

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Hauptverfasser: Das, Atze T., Vink, Monique, Berkhout, Ben
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC548477/
https://ncbi.nlm.nih.gov/pubmed/15709038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.5.3179-3181.2005
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