Improving the Safety of a Conditional-Live Human Immunodeficiency Virus Type 1 Vaccine by Controlling both Gene Expression and Cell Entry

Live attenuated human immunodeficiency virus type 1 (HIV-1) vaccines are considered unsafe because faster-replicating pathogenic virus variants may evolve after vaccination. We previously presented a conditional-live HIV-1 variant of which replication can be switched off as an alternative vaccinatio...

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Bibliographic Details
Main Authors: Das, Atze T., Baldwin, Chris E., Vink, Monique, Berkhout, Ben
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075741/
https://ncbi.nlm.nih.gov/pubmed/15731280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3855-3858.2005
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