Multiple antigens of Yersinia pestis delivered by live recombinant attenuated Salmonella vaccine strains elicit protective immunity against plague

Based on our improved novel Salmonella vaccine delivery platform, we optimized the recombinant attenuated Salmonella Typhimurium vaccine (RASV) χ12094 to deliver multiple Y. pestis antigens. These included LcrV196 (amino acids, 131 to 326), Psn encoded on pYA5383 and F1 encoded in the chromosome, th...

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Vydáno v:Vaccine
Hlavní autoři: Sanapala, Shilpa, Rahav, Hannah, Patel, Hetal, Sun, Wei, Curtiss, Roy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484397/
https://ncbi.nlm.nih.gov/pubmed/27060051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.03.094
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