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A Recombinant Attenuated Yersinia pseudotuberculosis Vaccine Delivering a Y. pestis YopE(Nt138)-LcrV Fusion Elicits Broad Protection against Plague and Yersiniosis in Mice
In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (χ10069) engineered with ΔyopK ΔyopJ Δasd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopE(Nt138)-LcrV), to Swiss Webster mice as a protective antigen against inf...
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| Udgivet i: | Infect Immun |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6759313/ https://ncbi.nlm.nih.gov/pubmed/31331960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00296-19 |
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