Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting

BACKGROUND: Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of two randomized controlled primary prevention trials (ASCOT and JUPITER), statin therapy led to a greater relative risk reduction among a subgroup at high g...

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Detaylı Bibliyografya
Yayımlandı:Circulation
Asıl Yazarlar: Natarajan, Pradeep, Young, Robin, Stitziel, Nathan O., Padmanabhan, Sandosh, Baber, Usman, Mehran, Roxana, Sartori, Samantha, Fuster, Valentin, Reilly, Dermot F., Butterworth, Adam, Rader, Daniel J., Ford, Ian, Sattar, Naveed, Kathiresan, Sekar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484076/
https://ncbi.nlm.nih.gov/pubmed/28223407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024436
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