Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting

BACKGROUND: Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of two randomized controlled primary prevention trials (ASCOT and JUPITER), statin therapy led to a greater relative risk reduction among a subgroup at high g...

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Pubblicato in:Circulation
Autori principali: Natarajan, Pradeep, Young, Robin, Stitziel, Nathan O., Padmanabhan, Sandosh, Baber, Usman, Mehran, Roxana, Sartori, Samantha, Fuster, Valentin, Reilly, Dermot F., Butterworth, Adam, Rader, Daniel J., Ford, Ian, Sattar, Naveed, Kathiresan, Sekar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484076/
https://ncbi.nlm.nih.gov/pubmed/28223407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024436
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