Polygenic risk score identifies subgroup with higher burden of atherosclerosis and greater relative benefit from statin therapy in the primary prevention setting

BACKGROUND: Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of two randomized controlled primary prevention trials (ASCOT and JUPITER), statin therapy led to a greater relative risk reduction among a subgroup at high g...

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Opis bibliograficzny
Wydane w:Circulation
Główni autorzy: Natarajan, Pradeep, Young, Robin, Stitziel, Nathan O., Padmanabhan, Sandosh, Baber, Usman, Mehran, Roxana, Sartori, Samantha, Fuster, Valentin, Reilly, Dermot F., Butterworth, Adam, Rader, Daniel J., Ford, Ian, Sattar, Naveed, Kathiresan, Sekar
Format: Artigo
Język:Inglês
Wydane: 2017
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484076/
https://ncbi.nlm.nih.gov/pubmed/28223407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.024436
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