KAT–independent gene regulation by Tip60 promotes ESC self-renewal but not pluripotency

Although histone-modifying enzymes are generally assumed to function in a manner dependent on their enzymatic activities, this assumption remains untested for many factors. Here we show the Tip60 (Kat5) lysine acetyltransferase (KAT), which is essential for embryonic stem cell (ESC) self-renewal and...

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Udgivet i:Cell Rep
Main Authors: Acharya, Diwash, Hainer, Sarah J., Yoon, Yeonsoo, Wang, Feng, Bach, Ingolf, Rivera-Pérez, Jaime A., Fazzio, Thomas G.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5484067/
https://ncbi.nlm.nih.gov/pubmed/28445719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.001
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