Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts

Replication origins are licensed for a single initiation event by the loading of Mcm2-7 proteins during late mitosis and G1. Sequential associations of origin recognition complex, Cdc6 and Mcm2-7 are essential for completion of the licensing. Although Cdt1 also binds to the chromatin when the licens...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Tsuyama, Takashi, Tada, Shusuke, Watanabe, Saori, Seki, Masayuki, Enomoto, Takemi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2005
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC548366/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15687385/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gki226
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