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Evaluating Mendelian nephrotic syndrome genes for evidence of risk alleles or oligogenicity that explain heritability

BACKGROUND: More than 30 genes can harbor rare exonic variants sufficient to cause nephrotic syndrome (NS), and the number of genes implicated in monogenic NS continues to grow. However, outside the first year of life, the majority of affected patients, particularly in ancestrally mixed populations,...

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Detalhes bibliográficos
Publicado no:Pediatr Nephrol
Main Authors: Crawford, Brendan D., Gillies, Christopher E., Robertson, Catherine C., Kretzler, Matthias, Otto, Edgar, Vega-Wagner, Virginia, Sampson, Matthew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483602/
https://ncbi.nlm.nih.gov/pubmed/27766458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00467-016-3513-3
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