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Membrane-spanning α-helical barrels as tractable protein-design targets

The rational (de novo) design of membrane-spanning proteins lags behind that for water-soluble globular proteins. This is due to gaps in our knowledge of membrane-protein structure, and experimental difficulties in studying such proteins compared to water-soluble counterparts. One limiting factor is...

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Dades bibliogràfiques
Publicat a:Philos Trans R Soc Lond B Biol Sci
Autors principals: Niitsu, Ai, Heal, Jack W., Fauland, Kerstin, Thomson, Andrew R., Woolfson, Derek N.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5483516/
https://ncbi.nlm.nih.gov/pubmed/28630153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2016.0213
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