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The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis

Prostate cancer is often slowly progressive, and it can be difficult to treat with conventional cytotoxic drugs. Nonsteroidal antiinflammatory drugs inhibit the development of prostate cancer, but the mechanism of chemoprevention is unknown. Here, we show that the R-enantiomer of the nonsteroidal an...

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Main Authors: Kolluri, Siva Kumar, Corr, Maripat, James, Sharon Y., Bernasconi, Michele, Lu, Desheng, Liu, Wen, Cottam, Howard B., Leoni, Lorenzo M., Carson, Dennis A., Zhang, Xiao-kun
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC548323/
https://ncbi.nlm.nih.gov/pubmed/15699354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409721102
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