The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis

Prostate cancer is often slowly progressive, and it can be difficult to treat with conventional cytotoxic drugs. Nonsteroidal antiinflammatory drugs inhibit the development of prostate cancer, but the mechanism of chemoprevention is unknown. Here, we show that the R-enantiomer of the nonsteroidal an...

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Autori principali: Kolluri, Siva Kumar, Corr, Maripat, James, Sharon Y., Bernasconi, Michele, Lu, Desheng, Liu, Wen, Cottam, Howard B., Leoni, Lorenzo M., Carson, Dennis A., Zhang, Xiao-kun
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC548323/
https://ncbi.nlm.nih.gov/pubmed/15699354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409721102
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