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IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation

Genetic factors are known to strongly influence susceptibility to allergic inflammation. The Th2 cytokine IL-13 is a central mediator of allergy and asthma, and common single-nucleotide polymorphisms in IL13 are associated with allergic phenotypes in several ethnically diverse populations. In partic...

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Détails bibliographiques
Auteurs principaux: Vladich, Frank D., Brazille, Susan M., Stern, Debra, Peck, Michael L., Ghittoni, Raffaella, Vercelli, Donata
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2005
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC548315/
https://ncbi.nlm.nih.gov/pubmed/15711639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522818
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