Chemical carcinogenesis: too many rodent carcinogens.
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proporti...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54830/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2217209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.19.7772 |
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