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Chemical carcinogenesis: too many rodent carcinogens.

The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proporti...

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Detalhes bibliográficos
Main Authors: Ames, B N, Gold, L S
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC54830/
https://ncbi.nlm.nih.gov/pubmed/2217209
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