MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma

Despite the importance of the RAS-RAF-MAPK pathway in normal physiology and disease of numerous organs, its role during pituitary development and tumourigenesis remains largely unknown. Here, we show that the over-activation of the MAPK pathway, through conditional expression of the gain-of-function...

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Vydáno v:Development
Hlavní autoři: Haston, Scott, Pozzi, Sara, Carreno, Gabriela, Manshaei, Saba, Panousopoulos, Leonidas, Gonzalez-Meljem, Jose Mario, Apps, John R., Virasami, Alex, Thavaraj, Selvam, Gutteridge, Alice, Forshew, Tim, Marais, Richard, Brandner, Sebastian, Jacques, Thomas S., Andoniadou, Cynthia L., Martinez-Barbera, Juan Pedro
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2017
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482995/
https://ncbi.nlm.nih.gov/pubmed/28506993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.150490
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