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Electroporation as a vaccine delivery system and a natural adjuvant to intradermal administration of plasmid DNA in macaques

In vivo electroporation (EP) is used to enhance the uptake of nucleic acids and its association with DNA vaccination greatly stimulates immune responses to vaccine antigens delivered through the skin. However, the effect of EP on cutaneous cell behavior, the dynamics of immune cell recruitment and l...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Todorova, Biliana, Adam, Lucille, Culina, Slobodan, Boisgard, Raphaël, Martinon, Frédéric, Cosma, Antonio, Ustav, Mart, Kortulewski, Thierry, Le Grand, Roger, Chapon, Catherine
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482824/
https://ncbi.nlm.nih.gov/pubmed/28646234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04547-2
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