Towards better dose individualisation: metabolic phenotyping to predict cabazitaxel pharmacokinetics in men with prostate cancer

BACKGROUND: Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into accou...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Janssen, A, Verkleij, C P M, van der Vlist, A, Mathijssen, R H J, Bloemendal, H J, ter Heine, R
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
Subjects:
Translational Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482735/
https://ncbi.nlm.nih.gov/pubmed/28399110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.91
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