Testosterone Diminishes Cabazitaxel Efficacy and Intratumoral Accumulation in a Prostate Cancer Xenograft Model()

Inactivation of the androgen receptor (AR) pathway by androgen deprivation therapy (ADT) is the mainstay of (metastatic) prostate cancer therapy. Ultimately, the AR pathway will be re-activated despite castrate levels of circulating androgens. Thereby, maintaining its role even in castration resista...

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Sparad:
Bibliografiska uppgifter
I publikationen:EBioMedicine
Huvudupphovsmän: Mout, Lisanne, de Wit, Ronald, Stuurman, Debra, Verhoef, Esther, Mathijssen, Ron, de Ridder, Corrina, Lolkema, Martijn, van Weerden, Wytske
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2017
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828553/
https://ncbi.nlm.nih.gov/pubmed/29276148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.12.024
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