Testosterone Diminishes Cabazitaxel Efficacy and Intratumoral Accumulation in a Prostate Cancer Xenograft Model()

Inactivation of the androgen receptor (AR) pathway by androgen deprivation therapy (ADT) is the mainstay of (metastatic) prostate cancer therapy. Ultimately, the AR pathway will be re-activated despite castrate levels of circulating androgens. Thereby, maintaining its role even in castration resista...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Mout, Lisanne, de Wit, Ronald, Stuurman, Debra, Verhoef, Esther, Mathijssen, Ron, de Ridder, Corrina, Lolkema, Martijn, van Weerden, Wytske
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828553/
https://ncbi.nlm.nih.gov/pubmed/29276148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.12.024
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