Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase

The clinical availability of small molecule inhibitors specifically targeting mutated BRAF marked a significant breakthrough in melanoma therapy. Despite a dramatic anti-tumour activity and improved patient survival, rapidly emerging resistance, however, greatly limits the clinical benefit. The majo...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Kosnopfel, Corinna, Sinnberg, Tobias, Sauer, Birgit, Niessner, Heike, Schmitt, Anja, Makino, Elena, Forschner, Andrea, Hailfinger, Stephan, Garbe, Claus, Schittek, Birgit
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482615/
https://ncbi.nlm.nih.gov/pubmed/28415756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16204
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