Human melanoma cells resistant to MAPK inhibitors can be effectively targeted by inhibition of the p90 ribosomal S6 kinase

The clinical availability of small molecule inhibitors specifically targeting mutated BRAF marked a significant breakthrough in melanoma therapy. Despite a dramatic anti-tumour activity and improved patient survival, rapidly emerging resistance, however, greatly limits the clinical benefit. The majo...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kosnopfel, Corinna, Sinnberg, Tobias, Sauer, Birgit, Niessner, Heike, Schmitt, Anja, Makino, Elena, Forschner, Andrea, Hailfinger, Stephan, Garbe, Claus, Schittek, Birgit
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482615/
https://ncbi.nlm.nih.gov/pubmed/28415756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16204
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