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Tandem C(sp(3))–H Arylation/Oxidation and Arylation/Allylic Substitution of Isoindolinones
Isoindolinones comprise an important class of medicinally active compounds. Herein we report a straightforward functionalization of the isoindolinones with aryl bromides (22 examples) using a Pd(OAc)(2)/NIXANTPHOS-based catalyst system. Additionally 3-aryl 3-hydroxy isoindolinone derivatives, which...
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| Udgivet i: | Adv Synth Catal |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5482541/ https://ncbi.nlm.nih.gov/pubmed/28652858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.201600654 |
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