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Resolving sub-cellular miRNA trafficking and turnover at single-molecule resolution

Regulation of miRNA localization and stability is critical for their extensive cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have developed single-molecule fluorescence-based tools to assess the sub-cellular trafficking, integrity and activity of miRNAs. We find that se...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Pitchiaya, Sethuramasundaram, Heinicke, Laurie A., Park, Jun I., Cameron, Elizabeth J., Walter, Nils G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482240/
https://ncbi.nlm.nih.gov/pubmed/28423324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.03.075
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