Functional and Metabolomic Consequences of K(ATP) Channel Inactivation in Human Islets

Loss-of-function mutations of β-cell K(ATP) channels cause the most severe form of congenital hyperinsulinism (K(ATP)HI). K(ATP)HI is characterized by fasting and protein-induced hypoglycemia that is unresponsive to medical therapy. For a better understanding of the pathophysiology of K(ATP)HI, we e...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Li, Changhong, Ackermann, Amanda M., Boodhansingh, Kara E., Bhatti, Tricia R., Liu, Chengyang, Schug, Jonathan, Doliba, Nicolai, Han, Bing, Cosgrove, Karen E., Banerjee, Indraneel, Matschinsky, Franz M., Nissim, Itzhak, Kaestner, Klaus H., Naji, Ali, Adzick, N. Scott, Dunne, Mark J., Stanley, Charles A., De León, Diva D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482088/
https://ncbi.nlm.nih.gov/pubmed/28442472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0029
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